universita degli studi magna graecia di catanzaro

We summarize the protocols for the management of adverse reactions to ERT, analyzing their advantages and disadvantages, and provide expert recommendations for their optimal management, to the best of current knowledge. Our study presents a review of the current literature on management of immune responses to ERT in c-IOPD as considered by an Italian study group of pediatric metabolists and immunologists in light of our shared patient experience. Several articles have been written on this disease over the last 10 years, but no univocal indications have been established. It is therefore very important to identify strategies to prevent and manage these complications. Enzymatic replacement therapy (ERT) with alglucosidase alfa is the only available treatment, but adverse immune reactions can reduce ERT’s effectiveness and safety. Supported by the findings of the work and in analogy with the exergy in thermodynamics, we introduce the concept of exordic systems: a system is exordic if it is topologically biased to transmit information efficiently.Ĭlassic infantile onset of Pompe disease (c-IOPD) leads to hypotonia and hypertrophic cardiomyopathy within the first days to weeks of life and, without treatment, patients die of cardiorespiratory failure in their first 1–2 years of life. We then used the Shannon Information Entropy to decode those signals and compute the information transported in the grid as a function of its small-world-ness ( $$$$ SW and there is no convenience in increasing indefinitely the number of active links in the system. We used a model of the brain in which neurons are described as agents that integrate the signals from other neurons and generate an output that spreads in the system.

Here, we provide a quantitative estimate of the efficiency of small world networks. However, despite the relevance of the argument, little is known about the effective enhancement of information in similar graphs. Mounting evidence suggests that communication is optimized in networks with a small world topology. Small world networks have recently attracted much attention because of their unique properties. Particularly, evidence on sperm DNA fragmentation (SDF) and pregnancy outcome is needed. These data might prompt to research the impact on LR-HPV genotype on male fertility. 15%) was found.Ĭonclusion: We found no difference in sperm conventional parameters in LR-HPV infected patients than in controls. No difference in the prevalence of astenozoospermia (30% vs. However, the prevalence of oligozoospermia was significantly higher in patients than controls (50% vs. Sperm concentration, total sperm count, sperm progressive motility, morphology, and leukocyte concentration did not differ between patients and controls. Patients with evidence for high risk (HR)-HPV infection previously or at the time of enrollment, and/or with severe oligozoospermia (sperm concentration. Material and methods: This was a retrospective case–control study including patients attending to our center for infertility. Aim: We aimed to evaluate the impact of seminal low-risk human Papillomavirus (LR-HPV) infection on sperm conventional parameters.

Universita degli studi magna graecia di catanzaro